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Challenge Dream Tangential Flow Filtration(TFF) System.jpg
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Challenge Dream Tangential Flow Filtration(TFF) System

Challenge Dream TFF Systems are versatile, automated tangential flow filtration systems customizable for clients ranging from laboratory to production scales. They offer high levels of automation, integration, and cost-effective solutions, making them ideal for a variety of filtration needs.

    Features

    01

    Suitable for R&D and production, flexible and multi-purpose 

    Challenge Dream can stably support all needs from process development to pilot-scale expansion and commercial production

    03

    Easy process parameter linear transfer

    As a GMP-compliant device, Challenge Dream meets the needs of both process exploration and production. During process development, it provides a stable and reliable development environment, and consistent process parameters lay the foundation for subsequent production scaling.

    02

    Smart operating system, easy to use and efficient

    Intelligent and automated operation, easy to use and efficient The flexible and compact plug-and-play hardware design enables the system to quickly switch between various application scenarios (UF/DF/MF) and between R&D and production. This not only greatly improves work efficiency and flexibility but also increases asset utilization.

    04

    Digitization of data recording

    Electronic data management, stable and reliable The excellent and user-friendly Challenge Navigator software provides an intelligent operating interface and a 21 CFR Part 11-compliant data management system, ensuring process stability and repeatability. By referencing the automated operation mode and program structure of commercial production equipment, it provides great convenience for scaling up or down production processes.

    [Applicable Products]Antibodies, vaccines, gene therapies, blood products, diagnostic reagents, antibiotics, biochemical products, traditional Chinese medicine, etc.

    [Applicable Processes]Harvesting, clarification, separation and purification, concentration, dialysis, buffer exchange, microfiltration experiments.

    Typical Application

    Bacterial Cell Collection / Cell Harvesting & Concentration Clarification of cell culture supernatant and lysates
    Protein concentration, purification, and buffer exchange Plasmid purification and concentration
    Concentration of viruses, virus-like particles, and viral vectors Separation, purification, and concentration of polysaccharide molecules
    Dialysis and diafiltration of latex and nanoparticles Diafiltration and concentration of liposomes
    Endotoxin removal from biological samples, antibiotic raw materials, and traditional Chinese medicine Endotoxin removal from buffers and cell culture media
    Removal of alcohol, concentration, and metal ion removal from blood products

    Hardware & Software & Service

    • Hardware

      Integration
      Designed with a compact layout and minimal dead volume to optimize operational efficiency;
      Incorporates an integrated spatial design for a sleek, streamlined, and visually appealing appearance.

      Strong Compatibility
      Compatible with a wide range of filtration components, including hollow fiber membranes, flat sheet membranes, and more;
      Designed for versatility, supporting applications from lab-scale to pilot-scale and commercial production.

      Flexible and Customizable Modular Design
      Integrates fluid handling, weighing, and detection modules from leading international brands, ensuring exceptional stability and reliability;
      Online sensors for pressure, conductivity, pH, flow rate, and UV can be freely configured or combined, with reserved space for future upgrades.

      Single-Use Technology Components
      Single-Use (SU) fluid-contact components can be effortlessly reused or replaced as needed, eliminating the need for cleaning validation, reducing cross-contamination risks, and improving process development efficiency.

    • Software

    • Service

    Process Method

    Method Method   Remarks
    Automatic   Concentration  Preset method, one-click start, allowing the system to calculate complex values for you
    Diafiltration
    Flush  
    Alkaline cleaning
    Filling
    Water Flux  
    TMP Optimization  
    Manual   Self-define   Process development, permission unlocked, allowing for more flexible methods

    Challenge Dream Specifications

    Item Description Specifications
    Filter Filter type Hollow fiber cartridges Flat plate cassettes
    Recommended processing capacity 05D-SU 20ml-5L 20ml-5L
    3P 20ml-10L 20ml-15L
    3D 20ml-15L 20ml-15L
    20P 10L-200L 10L-200L
    20D 10L-500L 15L-500L
    Recommended membrane area 05D-SU 50cm²-1000cm² 50cm²-1000cm²
    3P/3D 50cm²-3700cm² 50cm²-5000cm²
    20P/20D 0.1m²-2.5m² 0.1m²-2.5m²
    Basic Accessories Feed pump 05D-SU Quattroflow QF30SU, PP pump,Max flow 0.5LPM (liters per minute),4 bar pressure,1/8"barbed connector
    3P Easy-Load®peristaltic pump, MAX flow 2.3 LPM Compatible with13#, 14#, 16#, 25#, 17#, and 18# tubing sizes.
    3D Quattroflow QF150s,Stainless steel pump,MAX flow3 LPM,6 bar pressure,1/4"Tri-Clamp fittings
    20P Easy-Load®peristaltic pump，MAX flow13 LPM, Compatible with 26#,73#, 82# tubing sizes.
    20D Quattroflow QF1200s,Stainless steel pump, Max flow20 LPM,6 bar pressure,3/4"Tri-Clamp fittings
    Transfer pump 05D-SU Easy-Load®peristaltic pump, MAX flow2.3LPM,Compatible with 13#, 14#, 16#, 25#, 17#, and 18# tubing sizes.
    3P/3D Easy-Load®peristaltic pump, MAX flow2.3LPM,Compatible with 13#, 14#, 16#, 25#, 17#, and 18# tubing sizes.
    20P/20D Easy-Load®peristaltic pump, MAX flow2.3LPM,Compatible with 13#, 14#, 16#, 25#, 17#, and 18# tubing sizes.
    Pressure sensor Single-Use Pressure Sensor,PSU material; Pressure range:-7 ~75 psi (-0.48~5.2 bar)
    HMI IPC,stableand reliable; Pre-installed with“Challenge Navigator” software
    Automatic regulating valve(Retentate) Automatic adjustment of Transmembrane Pressure(TMP)
    Weighing unit 05D-SU Range 0-20Kg,±0.1g(Multiple specifications available)
    3P/3D Range 0-20Kg,±0.1g(Multiple specifications available)
    20P/20D Range 0-50Kg,±0.1g(Multiple specifications available)
    Magnetic stirring Integrated with the main circulation weighing system, adjustable speed, real-time parameter recording
    Liquid Container Replaceable, PSU sanitary-grade, low-residue
    Pipe Based on the process requirements, a variety of platinum-cured silicone hoses and thermoplastic pipelines that conform to the specified standards can be utilized.
    Holder Integrated hollow fiber cartridge holder, compact yet efficient in space utilization
    Automatic regulating valve(Permeate) The microfiltration process limits the permeate flow rate to prevent rapid membrane polarization and fouling
    Permeate unit Filteredunitwith weighing capability, neat and elegant
    Optional Accessories UV 200-800nm,Variable wavelength band
    pH 0-14
    Conductivity Temperature compensation,0.02-200ms/cm
    EnvironmentRequired Temperature 0-40℃
    Humidity 10-90%
    Body Design IP33,wipeable and washable
    Power Supply AC220V
    Dimension Feed unit 05D-SU 510*480*500(L*W*H)
    3P/3D 510*480*500(L*W*H)
    20P/20D 520*540*590(L*W*H)
    Transfer unit 05D-SU 210*270*100(L*W*H)
    3P/3D 210*270*100(L*W*H)
    20P/20D 460*440*210(L*W*H)
    Permeate unit 05D-SU 210*185*100(L*W*H)
    3P/3D 210*185*100(L*W*H)
    20P/20D 380*405*120(L*W*H)
    Weight 05D-SU 55kg
    3P 40kg
    3D 55kg
    20P 70kg
    20D 90kg
    Supporting Services Installation and Calibration Installation, commissioning, and training services, lasting 1-2 days, will be conducted either on-site or online.
    3Qservice 1-2 days of 3Qverificationwill be conducted either on-site or online, depending on the purchase of the 3Q service.
    Regular Maintenance Upon purchasing an annual maintenance contract, monthly and annual maintenance services, either online or on-site, will be provided.

    Remarks (processing capacity *): The specific values are related to the processing time and other process conditions.

    Other Specifications

    Specification Pump type flow range Environment
    Challenge Dream 05D-SU Diaphragm pump 0-0.5L/min 0-40℃
     10%-90%
    Challenge Dream 3D-SU Diaphragm pump 0-3L/min
    Challenge Dream 3D Diaphragm pump 0-3L/min
    Challenge Dream 3P Peristaltic pump 0-2.3L/min
    Challenge Dream 20P Peristaltic pump 0-13L/min
    Challenge Dream 20D Diaphragm pump 0-20L/min
    Challenge Dream 20D-SU Diaphragm pump 0-20L/min

    SU:Single use